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Figure 1 | BMC Bioinformatics

Figure 1

From: A transversal approach to predict gene product networks from ontology-based similarity

Figure 1

Transversal analysis steps. a) The GO terms are selected according to an a priori level of abstraction, b) From these selected terms, term vectors are obtained for each gene products through the application of the idf weighting scheme, c) The comparison of these vectors in a Vector Space Model results in a matrix of similarity, d) Standard expression clustering based methods result in the attribution of each gene products to an expression cluster (up-regulated cluster, down-regulated cluster and invariant cluster i.e. constant expression cluster), e) Based on higher pairwise similarity, the matrix of similarity is displayed as a biological network where the gene expression clustering corresponds to the shape and color of each node. Up-regulated and Down-regulated genes are represented respectively as red hexagons and green boxes.

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