Figure 5
From: A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality
Inter-complex interactions. Interactions in the E-2 complex map represent 4,411 of the 5,352 interactions in the PICO network at the E = 10-2 threshold. The 941 remaining protein-protein interactions (PPI) collapse to 248 complex-complex interactions. Here we map 128 inter-complex interactions, each comprising two or more protein-protein interactions (821 PPI total); singletons are omitted for clarity. Nodes represent E-2 complexes: yellow indicates >70% essential subunits; labels indicate highest-scoring GO component, where applicable. Edge thickness reflects number of interactions between complex subunits, ranging from two (thinnest) to 24 or more (thickest) PPI; number of interactions is shown on each edge. Density of PPI between complexes of similar function (e.g. 190 PPI from U4/U6/U5 tri-snRNP complex to neighbors; 86 PPI between C20/C30/C44/C78 ribosome biogenesis modules; 64 PPI linking C17 histone-associated complex to neighbors; shaded in blue) illustrates hierarchical nature of yeast complex network.