ROC curves for 8 different algorithms using three different yeast gene expression datasets. A) Chu,1998, sporulation; B) Primig,2000, sporulation;C) Cho,1998, cellCycle and the ChIP-chip data of Lee, 2002. KEGG pathways were used as the gold standard. ECIM utilizing both expression and binding data dominated all other algorithms. ROC "spots" for GRAM and SAMBA algorithms were obtained by applying the algorithms using the default parameters.