Table 3 Pathways enriched in subtype clusters: Enriched functional pathways in low and high grade tumor groups and within subtypes using DAVID [36] using a cutoff p < 0.01.
Group | Enriched pathway |
|---|---|
LG | lipid metabolism, transcriptional regulation, vesicle-mediated transport, amino-acid and derivative metabolism |
LG1 | small GTPase, mediated signal transduction, intracellular trafficking and vesicular transport |
LG2 | proteolysis collagens mRNA processing |
HG | mitotic cell cycle, ATM signaling pathway, role of BRCA1, BRCA2 and ATR in cancer susceptibility, cell cycle: G2/M checkpoint |
HG1 | ion transport |
HG2 | cell cycle proteolysis |
HG3 | collagens proteolysis |
HG4 | proteolysis |