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Table 1 Inter-module degrees (d), number of nodes (N), and main functions of the topological modules for H. sapiens network

From: Modular co-evolution of metabolic networks

Module d N Function category and Main Function
6 1 38 Metabolism of essential human nutrients: Arachidonic acid metabolism
24 1 41 Metabolism of essential human nutrients: Phenylalanine, Tyrosine metabolism
17 3 19 Metabolism of essential human nutrients: Valine, leucine and isoleucine degradation, Propanoate metabolism
12 4 20 Metabolism of essential human nutrients: One carbon pool by folate
21 7 21 Metabolism of essential human nutrients: Nicotinate and nicotinamide metabolism
19 1 34 Hormonal compound biosynthesis and metabolism: Androgen and estrogen metabolism
25 1 34 Hormonal compound biosynthesis and metabolism: C21-Steroid hormone metabolism
22 2 20 Hormonal compound biosynthesis and metabolism: Biosynthesis of steroids
20 5 28 Hormonal compound biosynthesis and metabolism: Fatty acid biosynthesis
7 2 26 Glycan biosynthesis and metabolism: Blood group glycolipid biosynthesis – neo-lactoseries
16 2 43 Glycan biosynthesis and metabolism: N-Glycan biosynthesis; Fructose and mannose metabolism
3 4 30 Glycan biosynthesis and metabolism: Blood group glycolipid biosynthesis – neo-lactoseries; Ganglioside biosynthesis
1 5 23 Glycan biosynthesis and metabolism: Glycosphingolipid metabolism
5 5 26 Glycan biosynthesis and metabolism: Aminosugars metabolism
14 1 17 Metabolism of cofactor: Hemoglobin and urobilinogen biosynthesis
4 8 41 *
15 11 24 *
2 13 47 *
23 14 56 *
9 17 42 *
18 17 46 *
10 21 58 *
8 22 66 *
13 25 57 *
11 30 91 *
  1. * represents that the corresponding module includes several pathways thus is difficult to assign it a simplex function.