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Table 2 Evolutionary ages of topological modules for H. sapiens network

From: Modular co-evolution of metabolic networks

Evolutionary age Module Percentage of enzymes in this age P-value Inter-module degree
6 3 82.35 % 9.26 × 10-8 4
6 6 68.75 % 2.46 × 10-4 1
6 7 71.43 % 6.19 × 10-3 2
6 19 63.16 % 3.02 × 10-4 1
6 25 85.71 % 1.58 × 10-6 1
4 24 30.00 % 2.22 × 10-3 1
3 20 40.00 % 4.18 × 10-2 5
3 22 33.33 % 2.34 × 10-3 2
2 1 36.84 % 1.89 × 10-2 5
2 5 40.00 % 6.82 × 10-3 5
1 8 69.09 % 4.27 × 10-5 22
1 9 84.38 % 3.5 × 10-6 17
1 12 65.22 % 2.53 × 10-2 4
1 13 65.31 % 6.48 × 10-4 25
1 15 64.00 % 2.65 × 10-2 11
1 18 68.57 % 1.61 × 10-3 17
  1. Evolutionary age is defined as: 1. Prokaryota; 2. Protists; 3. Fungi; 4. Nematodes; 5. Arthropods; 6. Mammalian; 7. Human. See Method part for the detailed definition.