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Table 2 Evolutionary ages of topological modules for H. sapiens network

From: Modular co-evolution of metabolic networks

Evolutionary age

Module

Percentage of enzymes in this age

P-value

Inter-module degree

6

3

82.35 %

9.26 × 10-8

4

6

6

68.75 %

2.46 × 10-4

1

6

7

71.43 %

6.19 × 10-3

2

6

19

63.16 %

3.02 × 10-4

1

6

25

85.71 %

1.58 × 10-6

1

4

24

30.00 %

2.22 × 10-3

1

3

20

40.00 %

4.18 × 10-2

5

3

22

33.33 %

2.34 × 10-3

2

2

1

36.84 %

1.89 × 10-2

5

2

5

40.00 %

6.82 × 10-3

5

1

8

69.09 %

4.27 × 10-5

22

1

9

84.38 %

3.5 × 10-6

17

1

12

65.22 %

2.53 × 10-2

4

1

13

65.31 %

6.48 × 10-4

25

1

15

64.00 %

2.65 × 10-2

11

1

18

68.57 %

1.61 × 10-3

17

  1. Evolutionary age is defined as: 1. Prokaryota; 2. Protists; 3. Fungi; 4. Nematodes; 5. Arthropods; 6. Mammalian; 7. Human. See Method part for the detailed definition.