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Table 3 Sensitivity of compound-feature combinations to cell segmentation

From: Impact of image segmentation on high-content screening data quality for SK-BR-3 cells

   Resistant Sensitive Overall Sensitive %
Channel Feature Type    
Ch1 arrangement 24 16 58%
  dimension 16 94  
  intensity 32 18  
  shape 33 27  
  texture 14 6  
Ch2 intensity 19 1 5%
Ch3 arrangement 6 14 47%
  intensity 36 14  
  texture 26 33  
Ch4 arrangement 10 20 46%
  dimension 7 3  
  intensity 57 33  
  shape 2 8  
  texture 32 28  
  1. The dose response of each feature for each drug was fitted by a linear model, using either the well-segmented cell population, or the poorly-segmented cell population. The discrepancy between the well- and poorly- segmented dose responses was calculated for each drug-feature combination, and drug-feature combinations were then binned as either sensitive to segmentation (if the discrepancy was larger than the grand median discrepancy) or resistant to segmentation (if the discrepancy was smaller than the grand median).