Figure 9
From: Statistical power of phylo-HMM for evolutionarily conserved element detection
Power comparison of phylo-HMM for different conservation ratio ( ρ ). (A) Comparing the whole ROC curves. The ROC curves shown are for different ρ as illustrated in the legend. The locations of the points correspond to a posterior probability threshold equal to 0.5. Some of the points are highlighted by crosses. The red dotted line crosses show the 1st-to-3rd quartile range. The black solid line crosses show the 95% bootstrap confidence interval of the median sensitivity and specificity. (B) The relationship between sensitivity and the conservation ratio at a fixed specificity equal to 0.9. The dots are where power was evaluated by simulation. The red whiskers at ρ = 0.3, 0.5, and ρ = 0.7 indicate the 95% bootstrap confidence interval for the median sensitivity. The red triangle indicates the power of the baseline, where ρ = 0.32.