Figure 4

Decision tree topology for the prediction of mitochondrial proteins. a, STACK-mem-DT; b, MTP-DT. The trees were built by C4.5 (see Methods). Each oval represents a prediction tool. Filled ovals represent transmembrane domain predictors. Rectangle represents a decision: "mit" for mitochondrial proteins and "non" for proteins of other subcellular locations. If a tool predicts the query protein as a mitochondrial protein, the branch (edge) is labeled "mit"; otherwise "non". If PASUB makes no prediction, the branch is labeled "N". Several decision-making paths are highlighted, as follows: Dotted line: for non-mitochondrial protein YDR378C. Grey line: for mitochondrial protein YOR297C. Blue arrow: the common path for three differently localized proteins: mitochondrial (YIL065C), plasma membrane (YBR069C) and nuclear (YLL022C). Orange arrow: for mitochondrial protein YIL065C. Red arrow: for non-mitochondrial protein YBR069C. Green arrow: for non-mitochondrial protein YLL022C.