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Table 4 Independent design meta analysis of case-control studies, 1 alternate scenario. 2

From: PedGenie: meta genetic association testing in mixed family and case-control designs

Description

CMH Chi Square

CMH Chi-Square Trend

Meta Odds Ratio

   

Aa vs. AA

aa vs. AA

Statistic, PedGenie 2.1

26.49

26.17

1.49

2.81

Empirical p-value, mean (SD)

<0.0001 (<0.0001)

<0.0001 (<0.0001)

<0.0001 (<0.0001)

0.0020 (0.0006)

Empirical 95% CI: lower (SD)

  

1.24(0.0031)

1.51 (0.0136)

Empirical 95% CI: upper (SD)

  

1.79 (0.0044)

5.24 (0.0475)

Statistic, SAS®

26.49

26.17

1.49

2.81

Standard p-value

<0.0001

<0.0001

<0.0001

0.0014

Standard 95% CI: lower

  

1.24

1.45

Standard 95% CI: upper

  

1.79

5.42

  1. 1Studies 1.1, 1.2, and 1.3.
  2. 210,000 configurations in the PedGenie null.