TDA on the CDK2 Activation Cycle. Fluctuation changes detected by TDA
are mapped to individual structures of the CDK2 activation cycle. To fully activate the kinase, a series of steps must occur involving (1) ATP binding, (2) cyclin A binding (cyclin not shown), and (3) T160 phosphorylation leading to (4) substrate binding (substrate not shown). Values have been normalized such that positive and negative values respectively indicate increasing (red) and decreasing (blue) fluctuations when compared to the previous conformational state. ATP is shown in yellow.