Figure 2

Significance of motifs evaluated using GOcardShuffle. Significance, evaluated by z-scores, of motifs also changes when annotation is included in the statistical analysis. We note that now all motifs of four nodes are over-represented in the true network, compared to the ensemble of conditionally randomized networks; interestingly the over-representation of the completely connected graph with 4 nodes (measured by its z-score) is halved once annotation has been taken into account.