Figure 3
From: Background frequencies for residue variability estimates: BLOSUM revisited
Testing the performance of H BB on several protein-protein interfaces. Sensitivity as a function of surface coverage for alignments of close homologues. Protein Databank Identifier of each protein is indicated in the corner of each panel. The results are based on sets of homologues very close to each query. In each case, all methods were applied to the same alignment. Full red line: joint entropy, evaluated according to Eq. 4; dashed green line: Shannon entropy; dashed blue line: rate4site.