Regulation of metabolic networks by small molecule metabolites

BMC Bioinformatics

Table 2 The ten compounds observed most commonly acting as regulators in E. coli, S. cerevisiae, H. sapiens and P. falciparum.

	E. coli		S. cerevisiae		H. sapiens		P. falciparum
Rank	Compound	Interactions	Compound	Interactions	Compound	Interactions	Compound	Interactions
1	ATP	70	ATP	65	ATP	51	ATP	56
2	ADP	70	ADP	52	Dithiothreitol	51	ADP	54
3	AMP	55	Orthophosphate	51	ADP	40	AMP	41
4	Orthophosphate	53	AMP	50	Orthophosphate	39	Orthophosphate	30
5	Mercaptoethanol	40	GTP	31	Mercaptoethanol	39	Pyrophosphate	29
6	Pyrophosphate	38	Pyrophosphate	31	AMP	31	GTP	28
7	GTP	35	Fe²+	26	Glutathione	30	CTP	23
8	Fe²+	35	NADH	25	Pyrophosphate	24	UTP	23
9	Glutathione	29	UTP	25	UTP	23	Adenosine	20
10	NADH	28	Glutathione	24	GTP	22	GDP	20

ISSN: 1471-2105