Regulation of metabolic networks by small molecule metabolites

BMC Bioinformatics

Table 3 Comparison of those compounds that have different importance in regulation between E. coli and H. sapiens.

		Rank		Interactions
No.	Compound	E. coli	H. sapiens	E. coli	H. sapiens
	More common in E. coli
1	Pyruvate	10	26	25	4
2	Phosphoenolpyruvate	15	28	19	2
3	2-oxoglutarate	16	27	18	3
4	Pyridoxal phosphate	15	26	19	4
5	D-fructose 1,6-bisphosphate	14	25	20	5
6	ITP	18	28	15	2
7	Succinate	15	25	19	5
8	Oxaloacetate	20	28	13	2
9	L-alanine	21	28	12	2
10	L-serine	20	27	13	3
	More common in H. sapiens
10	Nitric oxide	30	24	3	6
9	3'-5'-cyclic AMP	29	23	4	7
8	Phosphatidylethanolamine	28	22	5	8
7	UTP	12	7	22	23
6	Phosphatidate	30	23	3	7
5	Ethanol	25	18	8	12
4	1-acyl-glycero-3-phosphocholine	32	22	1	8
3	CDP	28	17	5	13
2	Phosphatidylserine	30	17	3	13
1	Phosphatidylcholine	28	13	5	17

The number of interactions (EC numbers regulated) for each compound in the two organisms is shown in the right most columns. The compounds are then ranked in each organism by the number of interactions. The ranks for each compound in the two organism are shown in the middle columns. The ten compounds showing the largest decrease in rank (i.e. those that are more important in H. sapiens and the ten compounds showing the largest increase in rank (more important in E. coli are shown.

ISSN: 1471-2105