Figure 4

Clustering result: Constrained Mixture of Gaussians. The 28 clusters from cMoG show tightly co-regulated patterns and a refinement of the clustering solution of MoG. In the clusters with zygotically expressed genes, we also observe two main periods of activation: 3–4 h for clusters c1 to c5, and 7–8 h hours for clusters c9 to c12. In the clusters with maternal genes, we observe under-expression of genes at several time periods: 3–4 h for clusters C18, C20 to C28; 4–5 h for clusters C15, C16, C19; 6–7 h for clusters C8, C13, C14 and C19; and 7–8 h hours for cluster C7.