Table 3 Genes involved in carcinogenesis altered by comfrey and riddelliine treatments in liver
From: Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver
Gene symbol | Gene description | Locus link ID | Fold changea | |
|---|---|---|---|---|
| Â | Â | Â | Comfrey | Riddelliine |
AKR1C3 | aldo-keto reductase family 1, member C3 | 171516 | -4.9 | -39.5 |
AR | androgen receptor (dihydrotestosterone receptor) | 24208 | -13.6 | -19.6 |
ARHGDIG | Rho GDP dissociation inhibitor (GDI) gamma | 14570 | -8.9 | -12.1 |
C5ORF13 | chromosome 5 open reading frame 13 | 338475 | -7.5 | -7.6 |
CAST | Calpastatin (includes EG:831) | 25403 | -3.3 | -5.4 |
CD36 | CD36 molecule (thrombospondin receptor) | 29184 | 3.3 | 7.9 |
CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 246060 | 5.1 | 2.7 |
CHEK1 | CHK1 checkpoint homolog (S. pombe) | 140583 | 2.1 | 2.5 |
CREM | cAMP responsive element modulator | 25620 | -2.6 | -3.3 |
DOK1 | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | 13448 | 4.5 | 2.9 |
ECGF1 | endothelial cell growth factor 1 (platelet-derived) | 72962 | -6.7 | -2.8 |
EGR1 | early growth response 1 | 24330 | 12.2 | 2.2 |
FABP2 | fatty acid binding protein 2 | 25598 | 3.3 | 2.7 |
FAS | Fas (TNF receptor superfamily, member 6) | 246097 | 3.3 | 3.2 |
FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | 81730 | -3.2 | 2.9 |
FUT1 | fucosyltransferase 1 | 81919 | -4.8 | -6.9 |
FYN | FYN oncogene related to SRC, FGR, YES | 25150 | 4.3 | 2.8 |
GDF15 | growth differentiation factor 15 | 29455 | 4.8 | 2.3 |
HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | 24446 | 3.6 | 2.4 |
HRASLS3 | HRAS-like suppressor 3 | 24913 | 3.0 | 4.0 |
HSPA1A | heat shock 70kDa protein 1A | 3303 | 4.1 | 8.1 |
ID1 | inhibitor of DNA binding 1, | 25261 | 3.9 | 2.2 |
IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 25662 | 3.2 | 15.7 |
ITGA4 | integrin, alpha 4 (antigen CD49D) | 16401 | 5.4 | 2.1 |
LAMA5 | laminin, alpha 5 | 3911 | 37.5 | 2.1 |
LIMK2 | LIM domain kinase 2 | 29524 | 4.1 | 2.0 |
MGAT5 | mannoside acetylglucosaminyltransferase 5 | 65271 | -2.2 | 2.1 |
MT1A | metallothionein 1A (functional) | 24567 | 5.8 | 12.2 |
NCR1 | natural cytotoxicity triggering receptor 1 | 117547 | 2.5 | 61.7 |
NQO1 | NAD(P)H dehydrogenase, quinone 1 | 24314 | 5.0 | 2.6 |
PPARG | peroxisome proliferative activated receptor, gamma | 25664 | -2.6 | -5.3 |
PRLR | prolactin receptor | 24684 | 29.8 | 284.4 |
PTK6 | PTK6 protein tyrosine kinase 6 | 20459 | -16.7 | -3.7 |
RTN4 | reticulon 4 | 83765 | 6.2 | 3.4 |
SERPINA5 | serpin peptidase inhibitor, clade A, member 5 | 65051 | -3.1 | -2.2 |
SMOX | spermine oxidase | 228608 | 2.0 | 2.3 |
ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 20440 | -2.7 | -5.7 |
ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | 25280 | -6.8 | -6.8 |
TIMP3 | TIMP metallopeptidase inhibitor 3 | 25358 | 2.1 | 2.1 |
TNF | tumor necrosis factor (TNF superfamily, member 2) | 24835 | -4.2 | -24.5 |
TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 246775 | 2.4 | 2.6 |
TUBG1 | tubulin, gamma 1 | 252921 | -3.2 | -4.2 |