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Table 3 Genes involved in carcinogenesis altered by comfrey and riddelliine treatments in liver

From: Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver

Gene symbol Gene description Locus link ID Fold changea
    Comfrey Riddelliine
AKR1C3 aldo-keto reductase family 1, member C3 171516 -4.9 -39.5
AR androgen receptor (dihydrotestosterone receptor) 24208 -13.6 -19.6
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 14570 -8.9 -12.1
C5ORF13 chromosome 5 open reading frame 13 338475 -7.5 -7.6
CAST Calpastatin (includes EG:831) 25403 -3.3 -5.4
CD36 CD36 molecule (thrombospondin receptor) 29184 3.3 7.9
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 246060 5.1 2.7
CHEK1 CHK1 checkpoint homolog (S. pombe) 140583 2.1 2.5
CREM cAMP responsive element modulator 25620 -2.6 -3.3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 13448 4.5 2.9
ECGF1 endothelial cell growth factor 1 (platelet-derived) 72962 -6.7 -2.8
EGR1 early growth response 1 24330 12.2 2.2
FABP2 fatty acid binding protein 2 25598 3.3 2.7
FAS Fas (TNF receptor superfamily, member 6) 246097 3.3 3.2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 81730 -3.2 2.9
FUT1 fucosyltransferase 1 81919 -4.8 -6.9
FYN FYN oncogene related to SRC, FGR, YES 25150 4.3 2.8
GDF15 growth differentiation factor 15 29455 4.8 2.3
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 24446 3.6 2.4
HRASLS3 HRAS-like suppressor 3 24913 3.0 4.0
HSPA1A heat shock 70kDa protein 1A 3303 4.1 8.1
ID1 inhibitor of DNA binding 1, 25261 3.9 2.2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 25662 3.2 15.7
ITGA4 integrin, alpha 4 (antigen CD49D) 16401 5.4 2.1
LAMA5 laminin, alpha 5 3911 37.5 2.1
LIMK2 LIM domain kinase 2 29524 4.1 2.0
MGAT5 mannoside acetylglucosaminyltransferase 5 65271 -2.2 2.1
MT1A metallothionein 1A (functional) 24567 5.8 12.2
NCR1 natural cytotoxicity triggering receptor 1 117547 2.5 61.7
NQO1 NAD(P)H dehydrogenase, quinone 1 24314 5.0 2.6
PPARG peroxisome proliferative activated receptor, gamma 25664 -2.6 -5.3
PRLR prolactin receptor 24684 29.8 284.4
PTK6 PTK6 protein tyrosine kinase 6 20459 -16.7 -3.7
RTN4 reticulon 4 83765 6.2 3.4
SERPINA5 serpin peptidase inhibitor, clade A, member 5 65051 -3.1 -2.2
SMOX spermine oxidase 228608 2.0 2.3
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 20440 -2.7 -5.7
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 25280 -6.8 -6.8
TIMP3 TIMP metallopeptidase inhibitor 3 25358 2.1 2.1
TNF tumor necrosis factor (TNF superfamily, member 2) 24835 -4.2 -24.5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 246775 2.4 2.6
TUBG1 tubulin, gamma 1 252921 -3.2 -4.2
  1. aThe symbol of minus (-) means down-regulation, and the P-value for all genes is less than 0.01.