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Figure 13 | BMC Bioinformatics

Figure 13

From: The α-Hemolysin nanopore transduction detector – single-molecule binding studies and immunological screening of antibodies and aptamers

Figure 13

Antibody-Antigen binding – clear example from specific capture orientation. A region of antibody molecule has inserted into the Alpha-hemolysin channel to produce a constant toggle signal. Antigen is introduced in frame (A). Sub-sequential data files containing toggle signals of three minute intervals are recorded and displayed as B, C, and D. Changes to the toggle signal are detected in frames C and D indicating the binding event between the antibody and antigen has taken place.

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