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Figure 2 | BMC Bioinformatics

Figure 2

From: Framework for a Protein Ontology

Figure 2

Schematic representation of the evolutionary relationship between human and mouse versions EPB42 and TGM3. Top panel: protein-glutamine gamma-glutamyltransferase (TGM3) and erythrocyte membrane protein band 4.2 (EPB42) are descended from a common ancestor with glutamyltransferase activity. Middle panel: All four proteins share a common domain arrangement. Bottom panel: PRO and GO connections. TGM3 and EBP42 are descended from an ancestral transglutaminase (TGase) represented by the large circle. This protein evolved into the ancestral forms of TGM3 and EPB42, represented by the ovals. All descendants of the ancestral TGase comprise the parts indicated by blue boxes. Except where indicated, all descendants of the ancestral TGase have transglutaminase activity and are involved in protein modification. However, the ancestral EPB42 lacks these attributes, and instead acquired new attributes not shared by the ancestral TGM3.

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