Clustering of cognate proteins among distinct proteomes derived from multiple links to a single seed sequence

BMC Bioinformatics

Table 2 Comparison of Seed Linkage usage under different iterations.

	Manual	RBH	One iteration	Convergence
Sequences	1363	1449	1605	1638
Clusters	221	402	302	263
Mean cluster size	6.2	3.6	5.3	*6.2*
Singlets	0	158	44	38
Originals in clusters	1363	1205	1319	1325
Sensitivity^a	100%	88%	*97%*	*97%*
Additionals	0	87	242	275
Additionals < 2 TM	0	6	28	36
Specificity^b	100%	*93%*	84%	83%
Specificity*^,c	100%	89%	*96%*	*96%*

^aSensitivity = Originals in clusters/Total of Manual Sequences; ^bSpecificity = True Positives/Total of Sequences; ^cSpecificity* was determined considering sequences with 2 or more TM domains as True Positives.

ISSN: 1471-2105