Figure 3

Co-expression-based disease gene rankings are improved by conservation at various evolutionary distances. Pairwise cross-species co-expression improves disease gene ranking over single-species datasets for comparisons between human and mouse (A), fruit fly (B), and nematode worm (C) co-expression. However, co-expression in yeast alone performs as well as co-expression conserved between human and yeast (D), and significantly better than human-only co-expression (p = 0.01).