Correlation of impact and value. Change in entropy S0 - S
after reaction knockouts and the average as a function of the average flux value ⟨ν⟩ of the unperturbed system. Red dots are relative to 75% knock-out and blue one to complete knock-out. The six red dots with average flux ~0.3 and entropy change larger than 0.15 are G1PP, GLCP, HEX1, CS, PDH, glycogen which are key check-points of central metabolism.