Figure 1
From: Identification and correction of abnormal, incomplete and mispredicted proteins in public databases
Error detected by MisPred routine for Conflict 1: the case of the Swiss-Prot entry LPLC4_HUMAN. The protein contains extracellular domains LBP_BPI_CETP and LBP_BPI_CETP_C but was found to lack both a signal peptide and transmembrane helices. The human sequence was corrected (LPLC4_HUMAN_corrected) by targeted search of the human genome with its mouse ortholog, CAM20161 [EMBL:CAM20161] that has a signal peptide. The alignment shows the N-terminal parts of LPLC4_HUMAN, CAM20161 and LPLC4_HUMAN_corrected. The predicted signal peptides of CAM20161 and LPLC4_HUMAN_corrected are in yellow and underlined.