Figure 4
From: Identification and correction of abnormal, incomplete and mispredicted proteins in public databases
Error detected by MisPred routine for Conflict 4: the case of the Swiss-Prot entry EPHA5_RAT. This protein contains a C-terminal truncated SAM_1 domain that deviates significantly from the normal size of this domain family. It is noteworthy that orthologs from mouse, human and chicken contain an intact SAM_1 domain. The sequence of this protein was corrected by targeted search of the rat genome using the sequences of the full-length orthologs. The alignment shows the C-terminal parts of EPHA5_RAT, EPHA5_RAT_corrected, EPHA5_MOUSE [Swiss-Prot:Q60629], EPHA5_HUMAN [Swiss-Prot:P54756] and EPHA5_CHICK [Swiss-Prot:P54755]. The region of the predicted SAM_1 domain of EPHA5_RAT_corrected that is absent in EPHA5_RAT is underlined and highlighted in yellow.