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Table 5 Over-represented annotation terms and pathways in genes selected by t-test.

From: Combining Shapley value and statistics to the analysis of gene expression data in children exposed to air pollution

Functional Category Term efc p-value
UP_SEQ_FEATURE cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in & ubiquitin) 6,320 0,000
GOTERM_MF_ALL guanyl nucleotide binding 2,344 0,000
GOTERM_MF_ALL GTP binding 2,256 0,001
INTERPRO_NAME IPR000217:Tubulin 6,384 0,001
INTERPRO_NAME IPR002452:Alpha tubulin 9,120 0,001
INTERPRO_NAME IPR008280:Tubulin/FtsZ, C-terminal 6,384 0,001
SP_PIR_KEYWORDS Ubl conjugation 7,089 0,001
INTERPRO_NAME IPR000558:Histone H2B 7,980 0,002
INTERPRO_NAME IPR001660:Sterile alpha motif SAM 4,966 0,002
GOTERM_CC_ALL Chromatin 2,683 0,003
SMART_NAME SM00427:H2B 7,422 0,003
INTERPRO_NAME IPR000047:Helix-turn-helix motif, lambda-like repressor 5,107 0,004
GOTERM_CC_ALL Chromosome 2,139 0,005
GOTERM_BP_ALL protein metabolism 1,243 0,005
SP_PIR_KEYWORDS gtp-binding 2,122 0,007
SP_PIR_KEYWORDS dna-binding 1,444 0,007
INTERPRO_NAME IPR003008:Tubulin/FtsZ, GTPase 5,804 0,008
SMART_NAME SM00454:SAM 4,453 0,008
PIR_SUPERFAMILY_NAME SF002306:tubulin 8,354 0,009
UP_SEQ_FEATURE nucleotide phosphate-binding region:GTP 2,107 0,013
KEGG_PATHWAY HSA04540:GAP JUNCTION 3,353 0,014
SP_PIR_KEYWORDS chromosomal protein 2,658 0,017
GOTERM_BP_ALL microtubule-based movement 3,257 0,017
GOTERM_BP_ALL macromolecule metabolism 1,154 0,019
GOTERM_BP_ALL chromatin assembly or disassembly 2,412 0,020
GOTERM_BP_ALL cytoskeleton-dependent intracellular transport 3,144 0,020
SP_PIR_KEYWORDS DNA binding 1,786 0,021
GOTERM_MF_ALL GTPase activity 2,252 0,021
UP_SEQ_FEATURE DNA-binding region:Homeobox 3,447 0,025
GOTERM_BP_ALL protein polymerization 3,398 0,027
UP_SEQ_FEATURE domain:SAM 5,618 0,028
INTERPRO_NAME IPR007124:Histone-fold/TFIID-TAF/NF-Y 2,883 0,030
GOTERM_MF_ALL DNA binding 1,272 0,034
GOTERM_BP_ALL glycoprotein biosynthesis 2,542 0,034
INTERPRO_NAME IPR007125:Histone core 3,192 0,035
GOTERM_BP_ALL tRNA metabolism 2,481 0,038
GOTERM_CC_ALL nucleosome 2,719 0,039
GOTERM_BP_ALL nucleosome assembly 2,682 0,041
GOTERM_CC_ALL cell surface 3,048 0,042
GOTERM_BP_ALL cellular macromolecule metabolism 1,176 0,043
UP_SEQ_FEATURE domain:SH3 2,408 0,043
SP_PIR_KEYWORDS nucleosome core 2,999 0,044
GOTERM_BP_ALL primary metabolism 1,087 0,044
GOTERM_MF_ALL binding 1,060 0,045
GOTERM_MF_ALL sequence-specific DNA binding 1,739 0,046
GOTERM_BP_ALL cellular protein metabolism 1,173 0,049
UP_SEQ_FEATURE repeat:Spectrin 5 7,584 0,053
UP_SEQ_FEATURE repeat:Spectrin 6 7,584 0,053
UP_SEQ_FEATURE repeat:Spectrin 7 7,584 0,053
UP_SEQ_FEATURE repeat:Spectrin 8 7,584 0,053
UP_SEQ_FEATURE repeat:Spectrin 9 7,584 0,053
GOTERM_CC_ALL obsolete cellular component 4,403 0,056
INTERPRO_NAME IPR002017:Spectrin repeat 2,483 0,058
GOTERM_BP_ALL anion transport 2,465 0,059
GOTERM_BP_ALL metabolism 1,070 0,062
GOTERM_MF_ALL purine nucleotide binding 1,255 0,062
GOTERM_BP_ALL cellular metabolism 1,073 0,068
GOTERM_MF_ALL transcription factor activity 1,398 0,068
GOTERM_MF_ALL L-ascorbic acid binding 6,552 0,071
GOTERM_BP_ALL regulation of mitosis 4,008 0,071
SP_PIR_KEYWORDS vitamin c 6,499 0,072
SMART_NAME SM00177:ARF 3,958 0,072
GOTERM_MF_ALL carboxylic ester hydrolase activity 2,621 0,073
GOTERM_BP_ALL chromatin assembly 2,338 0,073
INTERPRO_NAME IPR006162:Phosphopantetheine attachment site 6,384 0,074
INTERPRO_NAME IPR006620:Prolyl 4-hydroxylase, alpha subunit 6,384 0,074
GOTERM_CC_ALL microtubule cytoskeleton 1,816 0,076
GOTERM BP ALL microtubule-based process 2,127 0,077
GOTERM_MF_ALL nucleotide binding 1,206 0,083
SMART_NAME SM00702:P4Hc 5,938 0,084
GOTERM_MF_ALL nucleic acid binding 1,150 0,087
INTERPRO_NAME IPR001715:Calponin-like actin-binding 2,902 0,087
GOTERM_BP_ALL biopolymer metabolism 1,150 0,090
GOTERM_MF_ALL enzyme regulator activity 1,402 0,091
GOTERM_BP_ALL glycoprotein metabolism 2,043 0,091
SMART_NAME SM00033:CH 2,827 0,093
GOTERM_MF_ALL enzyme activator activity 1,737 0,097
INTERPRO_NAME IPR001526:CD59 antigen 5,472 0,098
INTERPRO_NAME IPR005123:2OG-Fe(II) oxygenase 5,472 0,098
INTERPRO_NAME IPR006703:AIG1 5,472 0,098
  1. Overview of significant over-represented functional themes and pathways within the lists of most significant 434 genes selected by t-test. Only functional terms and pathways with p-value smaller than 0.1 are listed.