Figure 4
From: In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites
Schematic representation of the results of threading analysis for typical C-MT containing sequence (from bleomycin ORF blmVIII) stretches having large length. The central stretch aligns with various methyltransferase crystal structures like 1VLM and 1QZZ. A 200 amino acid C-terminal stretch aligns with the structural half of the KR domain in the crystal structure 2FR0, a 60 amino acid N-terminal stretch shows alignment with the terminal stretch of the KS-AT di-domain structure 2HG4. The query sequence containing the MT domain is represented as a black line, while rectangular colored boxes represent matches with various structural folds. The corresponding structures are shown in the same color.