Figure 5

Multi biomarker profiles for the three differentiation measures. Comparison of the profiles of the same biomarkers by the (A) distance-based measure, (B) inverse nuclei density-based measure and (C) equidistant nuclei-based measure. In the profiles the individual biomarker are referenced by 1: integrin-α6, 2: desmoplakin, 3: keratin K1/10, 4: involucrin, 5: filaggrin. For each measuring point the standard deviation of the mean is plotted. For a comparison with experimental results an immunohistological staining for each biomarker is presented as well (D). SC = stratum corneum, CT = connective tissue.