High S pairs, prostate data. Sample plots of gene expression vs. pathway expression in normal (black circles) and tumor (red crosses) prostate samples. Loess curves (solid line) and least squares linear fits (dashed line) for the two classes are given as a visual guide. Marginal distributions of the data are given as rug plots (black, inward for normal samples; red, outward for tumor samples). From top to bottom: (a) ubiquitin specific peptidase 8 (USP8) vs. lysine biosynthesis pathway (SGPC = 0.824); (b) FGFR1 oncogene partner (FGFR1OP) vs. Jak-STAT signaling pathway (SGPC = 0.739); (c) mutS homolog 2, colon cancer (MSH2) vs. RNA polymerase pathway (SGPC = 0.713).