Ab-origin: an enhanced tool to identify the sourcing gene segments in germline for rearranged antibodies

BMC Bioinformatics

Table 1 Results of IGHV identification of 500 sampled sequences using six tools.

	Number of being rejected^a	Incorrect pickups of IGHV3-23^b	Correct pickups of IGHV3-23	Accuracy (%)^c
Ab-origin
IMGT\V-QUEST	0	1	499	~100
SoDA	1	0	499	~100
JOINSOLVER	1	17	482	96.4*
VDJsolver	0	0	500	100
iHMMune-align	24	0	476	95.2*

The numbers of correct and incorrect pickups are shown here, together with the number of input sequences which can't be deciphered (being rejected) by the six tools. A correct pickup is defined as a successful identification of IGHV3-23 gene within the 500 samples, allowing for mismatched alleles.
* Demonstrate that the accuracy of Ab-origin is significantly higher than that of this tool.
^a Number of the input sequences cannot be deciphered by the tool due to various reasons.
^b Number of the incorrect pickups among the sequences already been deciphered.
^c Accuracy = Correct pickups/500

ISSN: 1471-2105