Table 1 Pathways involved in the HIV-VLPs-induced PBMCs.
From: Gene expression profile of peripheral blood mononuclear cells in response to HIV-VLPs stimulation
Pathways | VLP vs PBS Up-regulated | Pathways | VLP vs PBS Down-regulated | |
|---|---|---|---|---|
Antigen processing and presentation | CTSL | ECM-receptor interaction | CD36 | |
Cell cycle, proliferation, cell death | IL3RA SMOX BCL2 G0S2 IER3 | Cytokine-cytokine receptor interaction | IL1R2 | |
Cell shape & extracellular matrix | SERPINB2 LIMK2 | Chaperones modulate interferon Signaling Pathway | HSPA7 | |
Chemokine and cytokines | IL6 PBFE1 PBX3 | |||
Cytokine Network | IL1-A IL1-B | |||
Cytokine-cytokine receptor interaction | CCL18 CCL20 CCL7 CXCL1 CXCL2 CXCL3 CXCL6 CXCL13 INHBA | |||
Immune response | ACTN1 | |||
Membrane proteins | AQP9 EMR1 SLC25A37 SLCO4A1 | |||
Transcription | MAD | |||
Selective expression of chemokine receptors during T-cell polarization/Toll-like receptor signaling pathway | CCL4 (MIP1β) CCL3 (MIP 1α) IL8 |