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Table 3 Comparison of the performances of the best sequence-based SVM method (SVM-WIN31) and structure-based SVM method (SVM-3D9) with the I-Mutant based predictors.

From: A three-state prediction of single point mutations on protein stability changes

Method

<Q>

<C>

Q[-]

P[-]

C[-]

Q[N]

P[N]

C[N]

Q[+]

P[+]

C[+]

I-Mutant Seq

0.52

0.13

0.59

0.46

0.34

0.73

0.55

0.11

0.00

0.00

−0.04

SVM-WIN31

0.55

0.24

0.45

0.51

0.33

0.64

0.58

0.16

0.45

0.51

0.32

I-Mutant 3D

0.54

0.22

0.70

0.43

0.35

0.72

0.61

0.25

0.00

0.33

0.01

SVM-3D9

0.58

0.33

0.55

0.51

0.37

0.62

0.67

0.29

0.55

0.51

0.37

  1. For notation see Table 1. I-Mutant SEQ, I-Mutant 3D, SVM-WIN31 and SVM-3D9 are tested on 982 mutations of NewDB database.
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BMC Bioinformatics

ISSN: 1471-2105

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