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Archived Comments for: In silico docking of urokinase plasminogen activator and integrins

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  1. alphaVbeta3 and uPA kringle do directly interact

    yoshi takada, UC Davis

    3 July 2009

    Good work. I just want to let you know that we have published a paper (below) that is relevant but not cited in this article. We demonstrated that alphaVbeta3 and uPA kringle directly interact and the interaction plays an important role in plasminogen activation. The authors discuss that the kringle domain "can" mediate the binding of uPA to integrins. Our paper showed it does.

    Thromb Haemost. 2006 Mar;95(3):524-34.
    Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation. By Tarui et al.

    Competing interests

    None declared