Figure 6

Residues of αvβ3 in the closed conformation and of urokinase kringle domain which are differentially exposed upon binding. In panel A the α and β chains of αvβ3 are shown as pale pink and yellow spheres respectively. Residues whose accessibility to the solvent changes by more than 10% upon kringle binding to αvβ3 in the closed conformation are highlighted in blue or green in the α or β chain, respectively.

In panel B the kringle domain of urokinase is shown as salmon spheres. Residues whose accessibility to the solvent changes by more than 10% upon binding onto αvβ3 in the closed conformation are highlighted in red. In any case, only those residues differently exposed in the poses ranking eighth, ninth and twelfth are highlighted.