Figure 2
From: Efficient prediction of human protein-protein interactions at a global scale
Distribution of the interacting protein pairs on the basis of subcellular localization (A), molecular function (B) and cellular process (C) for both previously detected interactions and interactions unique to this study normalized by the number of possible pairs with both GO terms. The overall co-occurrence (association) for pairs that were previously not reported is similar to that of previously reported interactions. The observed enrichment for certain categories within predicted interactions may represent new association or cross-communication. For example, in panel B, a co-occurrence (association) for “metal ion binding” and “transcription” is observed for predictions that were not previously reported. Similarly, in panel C, “immune response” and “signal transduction” have a more profound association among the predicted interacting pairs in this study.