Figure 1

Core CCK2R network and novel candidate regulators. The core of the gastrin mediated signal transduction network (CCK2R), and the novel candidate regulators resulting from our queries are shown. The CCK2R DbTFs that were targeted in our queries are colored light green. The network components in grey and the solid lines connecting them are part of the core CCK2R network and documented as regulators of the CCK2R DbTFs and respond to gastrin. The dotted lines represent new relations identified by the queries which could be verified against literature: blue pointed arrows denote ‘activation or positive influence’ and red bar-headed arrows depict ‘repression or negative influence’. CREB1 candidate regulators identified through Q1, Q2 and Q3 are colored yellow. Candidate regulators of NFκB1 identified through Q4 are colored turquoise, and candidate regulators of TCF7L2 identified through Q5 are colored orange. The target genes shared by the CCK2R DbTFs (CREB1 and NFκB1) and the DbTF candidates identified through Q6 are colored light red (JUN and BRCA2) and their connections are shown as solid arrows.