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Table 2 Validation of annotations derived from plus-rules

From: Methodology for the inference of gene function from phenotype data

Rule number Gene Phenotype terms included in rule Implied GO term   
   MP 1+ MP 2+ GO p-value Valid?
0 Foxl2 ovarian follicle development impaired ovarian folliculogenesis absent mature ovarian follicles 1.47E-36 yes
1 Mbd4 determination of left/right symmetry abnormal left-right axis patterning situs inversus 6.13E-36 yes
2 Ar spermatogenesis small testis decreased testis weight 3.47E-33 yes
2 Ar spermatogenesis small testis decreased testis weight 3.47E-33 yes
2 Ar spermatogenesis small testis decreased testis weight 3.47E-33 yes
2 Hsp90aa1 spermatogenesis small testis decreased testis weight 3.47E-33 yes
3 Psip1 anterior/posterior pattern specification thoracic vertebral transformation abnormal rib morphology 3.76E-33 yes
4 Fen1 lung development pulmonary hypoplasia decreased lung weight 2.48E-30 yes
5 Rag2 lymph node development absent Peyer's patches abnormal spleen morphology 6.82E-30 yes
6 Tapt1 anterior/posterior pattern specification thoracic vertebral transformation abnormal rib-sternum attachment 3.01E-29 yes
3072 Mir140 decreased body size decreased length of long bones collagen fibril organization 2.36E-08 no
3087 Fancm premature death abnormal ovary morphology cell proliferation 4.05E-08 yes
3091 Flnb abnormal angiogenesis decreased body weight angiogenesis 5.29E-08 yes
3096 Slc6a8 abnormal spatial learning decreased body weight learning or memory 6.56E-08 yes
3098 Tgfb1 abnormal extraembryonic tissue morphology decreased body size gastrulation with mouth forming second 8.17E-08 no
3099 Sirt1 decreased embryo size ventricular septal defect neural tube closure 8.29E-08 yes
3100 Kcnq1 deafness decreased body weight neuromuscular process controlling balance 1.06E-07 yes
3100 Slc12a7 deafness decreased body weight neuromuscular process controlling balance 1.06E-07 no
3101 Sall4 open neural tube premature death neural tube closure 1.09E-07 yes
3103 Pkhd1 respiratory failure postnatal growth retardation lung development 1.31E-07 no