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Figure 1 | BMC Bioinformatics

Figure 1

From: Rational selection of experimental readout and intervention sites for reducing uncertainties in computational model predictions

Figure 1

In silico example for profile likelihood sensitivity based experimental design. (a) Interaction structure of the in silico model. (b) Profile likelihood for the 6 model parameters given in silico time-course data of y= D. The blue cross indicates the MLE of θ i . The 95% point-wise significance is at \(\chi ^{2}_{\text {crit}}=3.68\). (c) Simulated extreme state trajectories along the profile likelihood for each parameter. (d) On the left side the temporal evolution of the PLS index s ij (t) is shown for each parameter (black) with j={A,B,C,D}. The corresponding criterion space derived from s ij (t) is shown on the right.

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BMC Bioinformatics

ISSN: 1471-2105

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