Table 6 Protease amino acid positions with mutations in at least 50% of the sequences by kmeans cluster

Cluster

Size

10

13

15

20

30

35

36

41

46

54

62

63

71

82

88

89

90

93

Cluster B6.1

2425

X

Cluster B6.2

1952

X

X

X

X

X

X

X

X

X

X

X

Cluster B6.3

1071

X

X

X

X

X

X

X

Cluster B6.4

1752

X

X

Cluster B6.5

1663

X

Cluster B6.6

1366

X

X

X

X

X

X

X

Cluster C6.1

53

X

X

X

X

X

X

X

X

Cluster C6.2

138

X

X

X

X

Cluster C6.3

114

X

X

X

X

Cluster C6.4

31

X

X

X

X

X

X

X

X

X

Cluster C6.5

52

X

X

X

X

X

X

X

X

X

X

X

Cluster C6.6

16

X

X

X

X

X

X

X

Cluster F6.1

89

X

X

X

X

X

X

X

X

X

Cluster F6.2

70

X

X

X

X

X

X

X

X

X

Cluster F6.3

81

X

X

X

X

X

X

X

X

X

X

X

X

Cluster F6.4

247

X

X

X

X

X

Cluster F6.5

98

X

X

X

X

X

X

X

X

X

X

X

Cluster F6.6

147

X

X

X

X