(A) True-positive rates TPR
for the top n=5,10,15,25 ranked candidates using Steps 1–4 of our prioritization method for all combinations of predefined values for the pI range (Δ) and Mw range (δ). (B) Gain (red) or loss (blue) in TPR w.r.t. the TPR reported in panel (A) when also performing gene expression-based filtering (Step 5). Combinations of pI and Mw range for which the TPR reaches its maximal value are indicated with solid black dots (without filtering) and open magenta dots (with filtering).