Figure 1
From: Measuring semantic similarities by combining gene ontology annotations and gene co-function networks
An example of GO structure and annotation, gene co-function network, and the functional distance. (A) GO structure and annotation. ta…tj and “root” are GO terms, edges are the ‘is-a’ (solid line) or ‘part-of’ (dashed line) relations between these terms, and {g 1 …g 13 } in boxes are the sets of genes annotated to the corresponding terms. (B) An example of a co-function network. Each node and edge represents a gene and a functional association between the genes, respectively. The number at each edge represents a confidence score that measures the probability of an interaction to represent a true functional linkage between the genes. (C) An example of the functional distance between two gene sets. G a (or G b ) is the set of genes annotated to t a (or t b ) or its descendants. The number at each edge represents the functional distance between the genes where 0 = functional identity and 1 = no functional relationship.