Figure 5

Single ChIP-seq sample analysis. a) Receiver operator characteristics curves show the sensitivity and specificity of different methods for H3K27me3 peak calls evaluated using qPCR validated regions. b-c) The association of region calls with gene expression is quantified using the t-statistic of gene expression values when comparing expression levels of genes with at least 50% overlap with modified regions to genes with less overlap. The barplots show the results for b) H3K27me3 and c) H3K9me3. Macs and Rseg have missing values because macs did not yield any gene with at least 50% overlap for H3K9me3, while Rseg did not yield any gene with less than 50% overlap for both modifications.