From: The effect of rare variants on inflation of the test statistics in case–control analyses
All variants | Variants < 20 heterozygotes | Variants ≥ 20 heterozygotes | ||||
---|---|---|---|---|---|---|
λ at median | λ at mean | λ at median | λ at mean | λ at median | λ at mean | |
LRT | 1.905 (1.903-1.906) | 1.172 (1.171-1.172) | 3.047 (3.047-3.047) | 1.270 (1.270-1.271) | 0.992 (0.991-0.992) | 1.002 (1.001-1.002) |
Wald test | 0.311 (0.310-0.311) | 0.580 (0.580-0.580) | 0.017 (0.017-0.017) | 0.343 (0.343-0.343) | 0.990 (0.989-0.991) | 0.987 (0.987-0.988) |
Score test | 1.902 (1.900-1.904) | 1.004 (1.004-1.004) | 2.198 (2.198-2.198) | 1.008 (1.008-1.009) | 0.991 (0.990-0.992) | 0.997 (0.996-0.997) |