Figure 2

The network of molecules involved in the control of VPC fate determination and the cell cycle in C. elegans . Pointed arrows are positive regulatory interactions, and blunt arrows are negative regulatory interactions. Purple arrows are interactions reported in other organisms, and green arrows are predictions of our model. Orange nodes are part of the Notch pathway, and blue nodes are part of the Ras/MAPK pathway or its targets (LIN-39). Green nodes are CDK/Cyclin complexes, yellow nodes are CDK inhibitors, EFL-1, a transcription factor in white, and protein degradation complexes in gray. The external signals are represented as elongated hexagons, the known transcription factors as ellipses, and other proteins as rounded rectangles.