Table 2 Negative feedback loops in the network of Figure 2

1

CDK-1/CYB-3 → APC ⊣

2

CKI-1 ⊣ CDK-1/CYB-3 →

3

SCF ⊣ CDK-2/CYE-1 →

4

CDK-4/CYD-1 ⊣ CKI-1 ⊣ CDK-1/CYB-3 ⊣

5

CKI-1 ⊣ CDK-1/CYB-3 → APC →

6

SCF ⊣ CDK-4/CYD-1 ⊣ CKI-1 ⊣ CDK-2/CYE-1 →

7

LIN-12i ⊣ MPK-1 → LIN-39 → LIN-12m →

8

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ CDK-2/CYE-1 →

9

CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 ⊣

10

SCF ⊣ CDK-4/CYD-1 ⊣ CDK-1/CYB-3 → APC ⊣

11

CKI-1 ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 →

12

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-2/CYE-1 →

13

CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → CKI-1 ⊣

14

SCF ⊣ CDK-4/CYD-1 ⊣ CDK-1/CYB-3 → CKI-1 ⊣ CDK-2/CYE-1 →

15

SCF ⊣ APC ⊣ CDK-1/CYB-3 → CKI-1 ⊣ CDK-2/CYE-1 →

16

CKI-1 ⊣ CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣ MPK-1 ⊣

17

CKI-1 ⊣ CDK-4/CYD-1 ⊣ CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 ⊣

18

CDK-4/CYD-1 ⊣ CKI-1 ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 →

CDK-1/CYB-3 ⊣

19

CKI-1 ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → APC →

20

CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → APC → CKI-1 ⊣

21

SCF ⊣ CDK-4/CYD-1 ⊣ CDK-1/CYB-3 → APC → CKI-1 ⊣

CDK-2/CYE-1 →

22

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ CKI-1 ⊣

CDK-2/CYE-1 →

23

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣

CDK-2/CYE-1 →

24

CKI-1 ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ LIN-35 → CDK-2/CYE-1 →

LIN-12i ⊣ MPK-1 ⊣

25

CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-2/CYE-1 →

LIN-12i ⊣ MPK-1 ⊣

26

SCF ⊣ CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 ⊣ CKI-1 ⊣ CDK-1/CYB-3 →

APC ⊣

27

SCF ⊣ CDK-4/CYD-1 ⊣ CKI-1 ⊣ CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 →

LIN-39 →

28

SCF ⊣ APC → CKI-1 ⊣ CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 →

LIN-39 →

29

SCF ⊣ APC → CKI-1 ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣

CDK-2/CYE-1 →

30

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 →

CDK-2/CYE-1 →

31

SCF ⊣ APC ⊣ CDK-1/CYB-3 → CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣

CDK-2/CYE-1 →

32

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 ⊣ LIN-12i ⊣

MPK-1 → LIN-39 →

33

SCF ⊣ APC → CKI-1 ⊣ CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣

MPK-1 → LIN-39 →

34

SCF ⊣ APC → CKI-1 ⊣ CDK-4/CYD-1 ⊣ CDK-1/CYB-3 ⊣ LIN-12i ⊣

MPK-1 → LIN-39 →

35

SCF ⊣ APC → CKI-1 ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣

EFL-1 → CDK-2/CYE-1 →

36

SCF ⊣ APC ⊣ CDK-1/CYB-3 → CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣

EFL-1 → CDK-2/CYE-1 →

37

SCF ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 ⊣ LIN-12i ⊣

MPK-1 → LIN-39 →

38

SCF ⊣ CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣ MPK-1 ⊣ CKI-1 ⊣

CDK-1/CYB-3 → APC ⊣

39

SCF ⊣ APC → CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ CDK-2/CYE-1 →

LIN-12i ⊣ MPK-1 → LIN-39 →

40

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 ⊣ CKI-1 ⊣

CDK-4/CYD-1 ⊣ LIN-35 → CDK-2/CYE-1 →

41

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 ⊣ LIN-12i ⊣

MPK-1 ⊣ CKI-1 ⊣ CDK-2/CYE-1 →

42

SCF ⊣ CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 ⊣ CKI-1 ⊣ CDK-4/CYD-1 ⊣

LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → APC ⊣

43

SCF ⊣ CDK-4/CYD-1 ⊣ CKI-1 ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 →

CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 → LIN-39 →

44

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-2/CYE-1 → LIN-12i ⊣

MPK-1 ⊣ CKI-1 ⊣ CDK-1/CYB-3 → APC ⊣

45

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → CKI-1 ⊣

CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 → LIN-39 →

46

SCF ⊣ APC → CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 →

CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 → LIN-39 →

47

SCF ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 ⊣

CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣ MPK-1 → LIN-39 →

48

SCF ⊣ CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣ MPK-1 ⊣ CKI-1 ⊣

CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → APC ⊣

49

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → APC →

CKI-1 ⊣ CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 → LIN-39 →

50

SCF ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → CKI-1 ⊣

CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣ MPK-1 → LIN-39 →

51

SCF ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → APC →

CKI-1 ⊣ CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣ MPK-1 → LIN-39 →