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Table 5 Binding free energies of WT EGFR-drug complex and several common mutation-drug complexes

From: EGFR Mutant Structural Database: computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib

EGFR Binding free energy with gefitinib (kcal/mol) Binding free energy with erlotinib (kcal/mol)
Total SD SEM Total SD SEM
WT −43.8839 2.7576 0.1950 −41.2009 3.0544 0.2160
L858R −46.0101 2.7728 0.1961 −45.1344 2.6856 0.1899
delE746_A750 −35.2995 2.9642 0.2096 −44.6007 3.3339 0.2357
delL747_P753insS −28.5837 3.6056 0.2550 −38.1157 3.0238 0.2138
delE746_S752insV −42.7755 3.1422 0.2222 −33.2645 2.9925 0.2116
G719S −35.4427 2.7781 0.1964 −43.4964 3.3155 0.2344