Figure 5

Host-pathogen interaction map. A) The cyan circles represent MTB proteins, while orange rectangles represent human proteins. The interactions are drawn as black lines, and the identified drug targets are colored yellow. An enlarged view of an interaction “island” (inset). B) A subnet involving rv1997, rv2299c, P40616, Q969Q4, P62330, and Q8N4G2. The map on the right was a human intraspecific interaction map. Points in yellow represent human proteins P40616, Q969Q4, P62330, and Q8N4G2. The other points are the direct interactors of these 4 proteins, and in these points, P10809 and P36532 as significant “hubs” in this sub-network are drawn in red points. Visualization was done with using Cytoscape [80].