Figure 2
From: Essentiality and centrality in protein interaction networks revisited
Centrality of e-MDSet proteins. (A) We determined the betweeness centrality of each protein in the interaction network of E. coli, S. cerevisiae and H. sapiens and chose the top 20% of proteins with highest betweeness centrality as sets of bottleneck proteins. Randomly sampling such sets 10,000 times, we observed that bottleneck proteins were weakly enriched with essential proteins in all organisms. In turn, MDSet and e-MDSet proteins were significantly enriched with bottleneck proteins. (B) Utilizing the subset of e-MDSet proteins in E. coli, S. cerevisiae (both in the inset) and H. sapiens, we sorted proteins according to their degree. Starting with the highest connected protein, we successively deleted proteins and calculated the number of connected components. To compare, we applied this procedure to a set of highest connected essential proteins of the same size in each organism. Our results suggest that the removal of e-MDSet proteins led to a lower number of deleted interactions and a higher number of connected components.