Figure 2

A summary of some of the key regulatory events distinguishing the two subnetworks. (A) Transcriptional factors that have significantly more targets in one of the subnetworks compared to the other (edge enrichment > 1.5, p < 1e-3). The differential expression and methylation of each transcription factor as well as the differential expression/methylation of its target genes (in the corresponding subnetwork) is noted. Color corresponds to direction of differential expression/methylation (red: higher in angiogenic, blue: higher in non-angiogenic). (B) Genetic functions associated with these key transcription factors describing their potential role in angiogenesis and ovarian cancer. (C) A distribution of the t-statistic for differential methylation across all the genes. The shift of the distribution to the right indicates an overall increase in methylation in the angiogenic compared to the non-angiogenic samples.