Figure 4
From: Optimally choosing PWM motif databases and sequence scanning approaches based on ChIP-seq data
Balanced accuracies for various approaches to threshold selection. Top row: balanced accuracy vs threshold parameter. Colors represent motif information content: from blue (low), through green and yellow to beige (high). Vertical black lines indicate optimal thresholds, black circles indicate corresponding average balanced accuracies. Bottom row shows how (sub-)optimal parameter values of a motif (X-axis) depends on its information content. For each motif, a circle represents parameter value yielding maximal balanced accuracy and a horizontal line represents a parameter range, for which BA is at least 95% of the maximum. Colors represent motif AUC: from green (low), through yellow to red (high). Balanced accuracies are calculated with respect to negative sequences composed of flanks of ChIP-seq peaks.