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Table 3 For each dataset of modENCODE 38955, the estimated r and π 0 from CisGenome (columns 2 and 3), from NCIS (columns 4 and 5), and from CCAT (columns 6 and 7)

From: Is this the right normalization? A diagnostic tool for ChIP-seq normalization

Dataset

CisGenome

NCIS

CCAT

 

\(\boldsymbol {\hat {r}}\)

\(\boldsymbol {\hat {\pi }_{0} = \frac {N_{\textit {in}}}{N_{\textit {ch}}}\hat {r}}\)

\(\boldsymbol {\hat {r}}\)

\(\boldsymbol {\hat {\pi }_{0} = \frac {N_{\textit {in}}}{N_{\textit {ch}}}\hat {r}}\)

\(\boldsymbol {\hat {r}}\)

\(\boldsymbol {\hat {\pi }_{0} = \frac {N_{\textit {in}}}{N_{\textit {ch}}}\hat {r}}\)

H3K27me3 (modENCODE,id 1820 vs id 1815)

0.6481

0.6587

0.6508

0.6615

0.5760

0.5855

H3K27me3 (modENCODE,id 1957 vs id 1961)

0.4883

0.6364

0.4933

0.6428

0.4251

0.5540

H3K27me3-pooled (modENCODE)

0.5464

0.6301

0.5656

0.6522

0.4660

0.5373

\(\frac {\hat {\pi }_{1820}N_{Ch_{1820}}+\hat {\pi }_{1957}N_{Ch_{1957}}}{N_{Ch_{1820}}+N_{Ch_{1957}}}\)

 

0.6473

 

0.6520

 

0.5694

  1. The last row shows an estimate of π 0 for the pooled sample based on a weighted average of the estimated π 0 in the two individuals samples.